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Dab2 interacting protein

Disabled homolog 2-interacting protein is a protein that in humans is encoded by the DAB2IP gene. DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers (Yano et al., 2005).[supplied by OMIM] WebFeb 15, 2024 · Disabled-2 (Dab2/DOC-2) is a mitogen-responsive adaptor protein required for multiple cellular functions. It is involved in many signaling pathways and plays an integral role in vesicular uptake and trafficking, modulating immune function, protein–protein interactions, cellular homeostasis and differentiation, oncogenesis, and inflammatory …

DAB2IP DAB2 interacting protein [ (human)]

WebMy project specifically focused on the potential action of a gene fusion ESR1-Dab2, isolated from metastatic breast cancer patients resistant to … WebJun 25, 2024 · Disabled homolog 2-interacting protein is a new member of the Ras GTPase-activating protein family. 26 The preferred name of DAB2IP is disabled homolog 2-interacting protein, also called ASK-interacting protein 1, ASK1-interacting protein 1, DAB2 interaction protein, DOC-2/DAB2 interactive protein, and nGAP-like protein. … east coast claims service https://primalfightgear.net

miR-1307-3p promotes tumor growth and metastasis of …

WebJan 1, 2024 · DAB2IP, DAB2 Interacting Protein; KIF3a, kinesin family member 3A; RCC, renal cell carcinoma; TCGA, The Cancer Genome Atlas. Discussion. Primary cilium is a microtubule-based structure that protrudes from the centrosomal mother centriole (also known as basal body) into the extracellular milieu [30]. Since cilium axoneme is … WebOct 4, 2016 · By interacting with other cellular factors through these motifs, Dab2 elicits its functions in endocytosis, differentiation, and immune response and is involved in the cell signaling pathways of Ras-mitogen activated protein kinase (MAPK), Wnt, TGF-β, c-Src and RhoA-ROCK [24, 27–36]. WebJun 16, 2003 · Identification of Dvl-3 as a Dab2-interacting protein. (A) Schematic representation of the small-pool cDNA screening strategy using GST–PID.(B) Schematic representation of the domain structure of Dvl … cube pdf tiff

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Dab2 interacting protein

DAB2IP DAB2 interacting protein [ (human)]

WebNov 18, 2016 · The cytoplasmic Ras-GAP protein DAB2IP (Disabled-2 Interacting Protein) is a negative modulator of multiple oncogenic pathways. DAB2IP is rarely mutated, but frequently downregulated or ...

Dab2 interacting protein

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WebSep 17, 2024 · Meanwhile, the DOC-2/DAB2 interacting protein DAB2IP was previously identified as a member of the Ras-GTPase activating protein family, and functions as a … http://www.cancerindex.org/geneweb/DAB2.htm

WebThe ELISA kits listed below target Dab2, the symbol for the human gene, DAB adaptor protein 2. The protein encoded by DAB2 has a predicted amino acid length of 770, a mass of 82.4 kDa, and a cytoplasmic subcellular localization. There are currently 3 reported isoforms. DAB2 may also be known by the following names: differentially-expressed ... WebJul 15, 2016 · Overall, Dab2 acts as a scaffold protein by interacting with many, but not all, cargo receptors, and by establishing simultaneous contacts at the site of endocytosis, favoring recruitment of other adaptor proteins that are essential for endocytosis to occur. Disabled‐2, an obligatory intermediary in developmental processes

WebOct 18, 2024 · Some GAPs can promote apoptosis of tumor cells to protect the organism. p120RasGAP, regulator of G-protein signaling 3 (RGS3), deleted in liver cancer 1 (DLC1), DOC-2/DAB2 interacting protein (DAB2IP), and STARD13 are typical examples because the five GAPs can influence the balance of antiapoptotic proteins and proapoptotic … WebApr 1, 2002 · Human DAB2IP (for DAB2 interaction protein) is a novel member of the RasGTPase-activating protein family. It interacts directly with DAB2, which suppresses growth of many cancer types. We demonstrated that DAB2IP is often downregulated in human prostate cancer cell lines. The predicted DAB2IP protein (967 amino acids) …

WebSep 17, 2024 · Meanwhile, the DOC-2/DAB2 interacting protein DAB2IP was previously identified as a member of the Ras-GTPase activating protein family, and functions as a tumor suppressor in cancer progression 7,8.

WebMay 18, 2010 · The N-terminal half of DAB2IP contains a protein kinase C (see 176960) conserved region-2 (C2) domain and a RasGAP domain. The C-terminal half contains a … cubepdf_utilityWeb智能制造网会员企业上海谷研实业有限公司提供人蛋白激酶Cα相互作用蛋白α1（PICK1）elisa酶联免疫试剂盒介绍,人蛋白激酶Cα相互作用蛋白α1(PICK1)elisa酶联免疫试剂盒介绍 的组成：的安全性：1． 避免直接接触终止液和底物A、B。一旦接触到这些液 … east coast circuits fire trucksWebdisabled homolog 2-interacting protein, ASK-interacting protein 1, DOC-2/DAB2 interactive protein, DOC2/DAB2 interactive protein GeneRIFs: Gene References Into Functions These findings suggest that Dab-2 is transiently upregulated and phosphorylated (particularly the p96 kDa isoform) in experimental autoimmune encephalomyelitis and … east coast classicsWebSep 1, 2024 · DAB2 interacting protein (DAB2IP) was screened as a direct target of miR-1307-3p. The expression of DAB2IP. mRNA was down-regulated and inversely correlated with miR-1307-3p level in HCC tissues ... east coast cities to visit in winterWebApr 1, 2002 · Dab2ip (DOC-2/DAB2 interacting protein) is a RasGAP protein which shows a growth-inhibitory effect in human prostate cancer cell lines. Recent studies have shown … cubepdf-utility-2.1.0-x64WebFeb 9, 2012 · This indicates that the interaction between Dab2 and a DPF-interacting protein is essential for Dab2 function when AP2 levels are low. This DPF-interacting … east coast classic college cupWeb大鼠脂蛋白脂酶(lpl)elisa检测试剂盒 ，产品常见搜索词： 大鼠脂蛋白脂酶(lpl)elisa检测试剂盒价格， 大鼠脂蛋白脂酶(lpl)elisa检测试剂盒品牌 ，公司专业供应elisa试剂盒产品，公司长足发展酶联免疫产品，全力打造elisa试剂盒网络超市，形成国内elisa试剂盒核航母，多国elisa试剂盒特权代理，给客户真 ... east coast classic cars inc