WebAn open, randomized, single-blind cross over trial to investigate phenytoin-digoxin interactions at steady state was performed in 6 healthy male volunteers. Coadministration of phenytoin caused a significant reduction in the elimination half-life of digoxin from 33.9 to 23.7 h and a diminution in AUC0–48 from 31.6 to 24.4 ng · ml−1 · h. Renal digoxin … WebMar 10, 2024 · Phenytoin may reverse digitalis-induced prolongation of the action potential in myocardial cells and may suppress digitalis-induced tachydysrhythmias. ... Tsai FH. Risk of digoxin intoxication caused by clarithromycin-digoxin interactions in heart failure patients: a population-based study. Eur J Clin Pharmacol. 2009 Dec. 65(12):1237-43. …
Drug Development and Drug Interactions Table of Substrates ...
WebSep 26, 2024 · Digoxin is a prescription drug. It comes as an oral tablet and an oral solution. Digoxin oral tablet is available as the brand-name drug Lanoxin.It’s also … WebJan 26, 2024 · Phenytoin is a commonly prescribed anticonvulsant used to treat most types of seizure disorders and status epilepticus, with the exception of absence seizures. … the haven woodbury
Biotin at High Concentration Interferes with the LOCI Digoxin
WebPhenytoin is an inducer of certain hepatic cytochrome P450 activities in humans and mice. There is evidence for the teratogenicity of phenytoin in humans ingesting 100–800 mg per day during the first trimester of … WebMar 21, 2024 · Other drug therapies, not discussed in this chapter, in which therapeutic drug monitoring is useful, include the anticonvulsant drugs carbamazepine, valproate and phenytoin; some drugs used to treat disturbances of cardiac rhythm (e.g. procainamide, quinidine) and a few antibiotics (e.g. gentamicin, vancomycin). WebApr 1, 2024 · Phenytoin Piketoprofen Piroxicam Pirtobrutinib Polythiazide Ponesimod Potassium Phosphate Pranoprofen Proglumetacin Propafenone ... —Dose of digoxin may be reduced 1 to 2 days prior to electrical cardioversion of atrial fibrillation to avoid worsening of the condition. Heart disease (e.g., amyloid heart disease, AV block, constrictive ... the haven wick